Maternal serum screening for fetal genetic disorders.
نویسندگان
چکیده
Maternal serum analyte screening is an integral component of contemporary antenatal care. Based on elevated MSAFP levels, 85% to 90% of NTDs (e.g., anencephaly or spina bifida) can be detected. Using a combination of serum analytes (e.g., MSAFP, hCG, UE3) 55% to 60% of fetal Down's syndrome can be detected. Future strategies for Down's syndrome screening may include the use of new markers such as dimeric inhibin-A and urinary beta-core fragment of hCG, as well as first-trimester screening, particularly with PAPP-A and free beta-hCG.
منابع مشابه
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ورودعنوان ژورنال:
- Obstetrics and gynecology clinics of North America
دوره 24 1 شماره
صفحات -
تاریخ انتشار 1997